Using the Point Group Symmetry dialog, changes to the geometry of a molecule via the bond, angle and dihedral sliders or via the X, Y and Z columns of the Atom List Editor can be constrained to preserve the current point group (or a specified subgroup) of the molecule.

Point group symmetry constraints also apply to changing an element type of an atom or atoms in the Atom List Editor.

Point group symmetry constraints also apply to changing an bond type of a bond in the Bond Semichem Smartslide dialog.

When point group symmetry constraints are active, replacing a target atom of a molecule with another atom or Builder fragment will simultaneously replace all other atoms which are symmetrically equivalent within the specified constraint group.  After a set of multiple-atom Builder fragment are placed, the resulting symmetry of the molecule may necessarily be less than the specified constraint group.